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KMID : 0191119970120060553
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Journal of Korean Medical Science
1997 Volume.12 No. 6 p.553 ~ p.558
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Alterations in the carnitine metabolism in epileptic children treated with valproic acid
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Chung S
Choi J/Hyun T/Rha Y/Bae C
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Abstract
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Serum concentrations of total carnitine, free carnitine and acylcarnitine were measured in forty-one
epileptic patients treated with valproic acid (VPA). Among them, 14 patients were on VPA monotherapy
and 27 were on VPA polytherapy. Forty-one age and sex matched healthy normal controls were also evaluated
for carnitine metabolism. The mean total and free carnitine were significantly lower in both the VPA
monotherapy and polytherapy groups compared with the controls. However, there were no significant
differences in concentrations of carnitine between the VPA polytherapy and VPA monotherapy groups.
Patients treated with VPA polytherapy had lower carnitine than those treated with VPA monotherapy.
An inverse correlation was found between serum concentrations of carnitine and duration of treatment
in patients treated with VPA. However, there was no significant correlations between serum concentrations
of carnitine and those of VPA. Also, correlation between serum concentrations of carnitine and the
activities of serum GOT and GPT was not significant. After L-carnitine supplementation in eleven
patients with hypocarnitinemia, the concentrations of carnitine were significantly increased.
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